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The mechanism is unknown and pharmacokinetic studies with hydrochlorothiazide have not demonstrated any effects on the disposition of allopurinol or oxipurinol (its major metabolite). The following information includes only the average doses of allopurinol. Keep Allopurinol out of the reach of children and away from pets. A 63-year-old man receiving allopurinol for gout developed progressive uremia, proteinuria, edema, and purpura after beginning quinidine therapy. A reaction with another antigout drug, allopurinol, may cause a rash.
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